Amidinothiourea

Nerv. Sist. 27 , 8-16, (1988)

Farmakol. Toksikol. 54(3) , 22-4, (1991)

The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were studied. Under normoxia gutimine inhibited the nerve cell re...

Biull. Eksp. Biol. Med. 109(1) , 72-4, (1990)

The ultrastructure of myocardium was studied in the experiments on rats during 24 hours after 6-min mechanical asphyxia with following clinical death. It has been established that the contractile cardiac apparatus of myocytes lesions on the intracellular edem...

Eksp. Klin. Farmakol. 55(2) , 63-4, (1992)

To measure drug antihypoxic activity, an electromyographic method was worked out. The main idea of the method is to estimate the influence of these substances on the amplitude of slow electric waves of smooth muscles on an isolated strip of rat small intestin...

Vestn. Ross. Akad. Med. Nauk (8) , 32-7, (2002)

The Fourie EEG spectral analysis of thr sensomotor cortex and dorsal hypocampus in freely moving rats could reveal the common pharmacological EEG effects of different antihypoxic agents (gutimin, amtizole, emoxipine, and 3-OPK). All the agents decreased the t...

Resuscitation 23(3) , 179-91, (1992)

Effect of acute lethal blood loss on character and frequency of cardiac arrhythmias in postresuscitation period has been studied. Experiments were carried out on mongrel male rats resuscitated after 4- and 6-min clinical death caused by acute blood loss. Elec...

Farmakol. Toksikol. 52(1) , 12-6, (1989)

The effects of some antihypoxants (piracetam, GABA, sodium hydroxybutyrate and gutimine) on the electrical activity of the cerebellar neurons (Purkinje cells) of rats and mice were studied in the surviving slices under normoxia and increasing hypoxia. All the...

Vopr. Med. Khim. 34(1) , 33-8, (1988)

Long-term impairments of energy metabolisms in myocardium were found in rats after clinical death caused by acute hemorrhage. Bioenergetics of myocardium tended to normalize within a month after resuscitation. Severity of postresuscitation period correlated w...

J. Comput. Chem. 31(6) , 1259-67, (2010)

Electronic structure analysis of guanylthiourea (GTU) and its isomers has been carried out using quantum chemical methods. Two major tautomeric classes (thione and thiol) have been identified on the potential energy (PE) surface. In both the cases conjugation...

Med. Hypotheses 40(6) , 335-41, (1993)

S-allylgutimine has immunostimulant and tumor cell inhibitory activities. This complex action may be a result of the stimulation of IL-2 production. The effectiveness of immunotherapy depends on the uncoupling of IL-2 downregulation. This principle can be wid...