GSK 2801
Modify Date: 2025-08-27 19:13:54
GSK 2801 structure
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Common Name | GSK 2801 | ||
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| CAS Number | 1619994-68-1 | Molecular Weight | 371.450 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H21NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK 2801GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd=136 nM) and BAZ2B(Kd=257 nM) bromodomains.IC50 value: 136 nM/257 nM(Kd, BAZ2A/BAZ2B) [1]Target: BAZ2A/2B inhibitorGSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures demonstrated a canonical acetyl-lysine competitive binding mode. Cellular activity was demonstrated using fluorescent recovery after photobleaching (FRAP) monitoring displacement of GFP-BAZ2A from acetylated chromatin. A pharmacokinetic study in mice showed that GSK2801 had reasonable in vivo exposure after oral dosing, with modest clearance and reasonable plasma stability. Thus, GSK2801 represents a versatile tool compound for cellular and in vivo studies to understand the role of BAZ2 bromodomains in chromatin biology. |
| Name | 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone |
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| Synonym | More Synonyms |
| Description | GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd=136 nM) and BAZ2B(Kd=257 nM) bromodomains.IC50 value: 136 nM/257 nM(Kd, BAZ2A/BAZ2B) [1]Target: BAZ2A/2B inhibitorGSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures demonstrated a canonical acetyl-lysine competitive binding mode. Cellular activity was demonstrated using fluorescent recovery after photobleaching (FRAP) monitoring displacement of GFP-BAZ2A from acetylated chromatin. A pharmacokinetic study in mice showed that GSK2801 had reasonable in vivo exposure after oral dosing, with modest clearance and reasonable plasma stability. Thus, GSK2801 represents a versatile tool compound for cellular and in vivo studies to understand the role of BAZ2 bromodomains in chromatin biology. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H21NO4S |
| Molecular Weight | 371.450 |
| Exact Mass | 371.119141 |
| LogP | 2.95 |
| Appearance of Characters | light yellow solid |
| Index of Refraction | 1.596 |
| InChIKey | KHWCPNJRJCNVRI-UHFFFAOYSA-N |
| SMILES | CCCOc1ccn2c(C(C)=O)cc(-c3ccccc3S(C)(=O)=O)c2c1 |
| Storage condition | -20℃ |
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Name: Binding affinity to biotinylated BRD9 (unknown origin) expressed in Escherichia coli ...
Source: ChEMBL
Target: Bromodomain-containing protein 9
External Id: CHEMBL5713042
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Name: Binding affinity to recombinant human TAF1L bromodomain-2 assessed as melting tempera...
Source: ChEMBL
Target: Transcription initiation factor TFIID subunit 1-like
External Id: CHEMBL3772747
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Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1
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Name: Thermal Shift Assay. Domain: start/stop: N44-E168
Source: ChEMBL
Target: Bromodomain-containing protein 4
External Id: CHEMBL5061265
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Name: Binding affinity to recombinant human BRD9 assessed as melting temperature shift at 1...
Source: ChEMBL
Target: Bromodomain-containing protein 9
External Id: CHEMBL3772746
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Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: Binding affinity to recombinant His6-TEV fused human BAZ2B assessed as melting temper...
Source: ChEMBL
Target: Bromodomain adjacent to zinc finger domain protein 2B
External Id: CHEMBL3772745
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Name: Binding affinity to biotinylated C-terminal Avi/His-TEV-tagged BAZ2A (unknown origin)...
Source: ChEMBL
Target: Bromodomain adjacent to zinc finger domain protein 2A
External Id: CHEMBL3773108
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Name: Binding affinity to biotinylated ATAD2 (unknown origin) expressed in Escherichia coli...
Source: ChEMBL
Target: ATPase family AAA domain-containing protein 2
External Id: CHEMBL3773107
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Name: Binding affinity to biotinylated ASH1L bromodomain (unknown origin) expressed in Esch...
Source: ChEMBL
Target: Histone-lysine N-methyltransferase ASH1L
External Id: CHEMBL3773106
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| 1-{1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl}ethanone |
| GSK 2801 |
| GSK2801 |