Suberosin

Modify Date: 2025-08-22 09:01:40

Suberosin structure	Common Name	Suberosin
	CAS Number	581-31-7	Molecular Weight	244.286
	Density	1.1±0.1 g/cm3	Boiling Point	393.3±42.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	166.0±22.5 °C

Use of Suberosin

Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

Name	7-methoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonym	More Synonyms

Description	Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312. [2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40.

Description

Related Catalog

Research Areas >> Inflammation/Immunology

References

[1]. Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.

[2]. Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40.

Density	1.1±0.1 g/cm3
Boiling Point	393.3±42.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₆O₃
Molecular Weight	244.286
Flash Point	166.0±22.5 °C
Exact Mass	244.109940
PSA	39.44000
LogP	3.87
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.557
InChIKey	RSZDAYHEZSRVHS-UHFFFAOYSA-N
SMILES	COc1cc2oc(=O)ccc2cc1CC=C(C)C

Hazard Codes	Xi

Precursor 9
CAS#:21422-04-8 Demethylsuberosin CAS#:74-88-4 methyl iodide CAS#:73490-50-3 Z-4,5-dimethoxy... CAS#:37761-51-6 4-methoxy-2-(3-...
CAS#:1099-45-2 Ethyl 2-(triphe... CAS#:673-22-3 2-Hydroxy-4-met... CAS#:531-59-9 7-Methoxycoumarin CAS#:120-08-1 Scoparone
CAS#:93-35-6 7-Hydroxycoumarine
DownStream 2
CAS#:129722-89-0 1,6-dihydroxy-3... CAS#:38409-28-8 7-Methoxy-6-(3,...

Name: Antitubercular activity against Mycobacterium tuberculosis assessed as growth inhibit...
Source: ChEMBL
Target: Mycobacterium tuberculosis
External Id: CHEMBL2339987

Name: Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate at 500 uM after...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL1936882

Name: Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins b...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL1936881

Name: Small-molecule inhibitors of ST2 (IL1RL1)
Source: 20881
Target: interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id: ST2_IL33_Inhibitors_Primary_Screening_77700

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

Name: Cytotoxicity against human PC3 cells after 3 days by MTT assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3756444

Name: Antitrypanosomal activity against Trypanosoma brucei brucei
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL1932146

Name: Inhibition of serum-opsonized zymosan-induced oxidative burst in whole blood (unknown...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3756443

Name: Antileishmanial activity against Leishmania donovani MHOM/ET/L82/LV9 promastigotes af...
Source: ChEMBL
Target: Leishmania donovani
External Id: CHEMBL1932145

Name: Cytotoxicity against african green monkey Vero cells
Source: ChEMBL
Target: Vero
External Id: CHEMBL1932147

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SUBEROSIN

7-Methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

7-Methoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one

7-methoxy-6-prenylcoumarin

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China
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Suberosin

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