PARP10-IN-2

Modify Date: 2024-01-14 09:38:23

PARP10-IN-2 structure	Common Name	PARP10-IN-2
	CAS Number	1042780-52-8	Molecular Weight	238.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₀N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PARP10-IN-2

PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].

Name	PARP10-IN-2

Description	PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	human PARP10:3.64 μM (IC50) human PARP15:11 μM (IC50) human PARP2:27 μM (IC50) human PARP12:>10 μM (IC50) human PARP16:>10 μM (IC50) human PARP1:>100 μM (IC50) human PARP3:>100 μM (IC50) human PARP4:>100 μM (IC50) human TNKS1:>100 μM (IC50) human TNKS2:>100 μM (IC50) human PARP14:>100 μM (IC50)
In Vitro	PARP10-IN-2 (化合物 10) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。
References	[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.

Molecular Formula	C₁₄H₁₀N₂O₂
Molecular Weight	238.24

PARP10-IN-2

Use of PARP10-IN-2

Names

PARP10-IN-2 Biological Activity

Chemical & Physical Properties