Topoisomerase I inhibitor 4
Modify Date: 2024-01-10 09:40:23
Topoisomerase I inhibitor 4 structure
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Common Name | Topoisomerase I inhibitor 4 | ||
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| CAS Number | 2485135-31-5 | Molecular Weight | 386.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H19FN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Topoisomerase I inhibitor 4Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1]. |
| Name | Topoisomerase I inhibitor 4 |
|---|
| Description | Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa)[1] |
| In Vitro | Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity[1]. Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells[1]. Cell Proliferation Assay[1] Cell Line: HepG2, A549, MCF-7 and HeLa cell lines Concentration: 0-40 μM Incubation Time: 48 hours Result: Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. |
| References |
| Molecular Formula | C23H19FN4O |
|---|---|
| Molecular Weight | 386.42 |