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85081-69-2

85081-69-2 structure
85081-69-2 structure
  • Name: TCO-OH
  • Chemical Name: 4-Cycloocten-1-ol, (4E)
  • CAS Number: 85081-69-2
  • Molecular Formula: C8H14O
  • Molecular Weight: 126.19600
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-10-13 11:43:27
  • Modify Date: 2024-01-05 16:50:07
  • TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 4-Cycloocten-1-ol, (4E)
Synonyms (E)-CYCLOOCT-4-ENOL
4-Cycloocten-1-ol, (E)-
(E)-Cyclooct-4-enol
Description TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C8H14O
Molecular Weight 126.19600
Exact Mass 126.10400
PSA 20.23000
LogP 1.86760
Storage condition 20°C
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes C
Risk Phrases 41-52
Safety Phrases 26-39
RIDADR NONH for all modes of transport