2222354-29-0

2222354-29-0 structure

Name: SNIPER(ABL)-039
Chemical Name: SNIPER(ABL)-039
CAS Number: 2222354-29-0
Molecular Formula: C₅₄H₆₈ClN₁₁O₉S₂
Molecular Weight: 1114.77
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
Create Date: 2019-06-01 18:45:17
Modify Date: 2024-01-05 11:42:34
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

Name	SNIPER(ABL)-039

Description	SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
Target	Abl:0.54 nM (IC50) cIAP1:10 nM (IC50) cIAP2:12 nM (IC50) XIAP:50 nM (IC50) SNIPER Abl:10 nM (DC50)
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Molecular Formula	C₅₄H₆₈ClN₁₁O₉S₂
Molecular Weight	1114.77