2222354-91-6
2222354-91-6 structure
- Name: SNIPER(ER)-87
- Chemical Name: SNIPER(ER)-87
- CAS Number: 2222354-91-6
- Molecular Formula: C59H73N5O10S
- Molecular Weight: 1044.30
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2019-12-08 06:48:54
- Modify Date: 2024-01-09 09:44:36
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SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2].
| Name | SNIPER(ER)-87 |
|---|
| Description | SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | SNIPER(ER)-87 (0.1-1000 nM; 72 hours) efficiently inhibits the ERα-dependent transcriptional activation by β-estradiol and suppresses the growth of ERα-positive breast tumor cells with IC50s of 15.6 nM in MCF-7 and 9.6 nM in T47D cells[1]. |
| In Vivo | SNIPER(ER)-87 (30 mg/kg, i.p., every 24 h for 14 days) inhibits the growth of MCF-7 orthotopic breast tumor xenografts in 6-week-old female BALB/c nude mice[1]. |
| References |
| Molecular Formula | C59H73N5O10S |
|---|---|
| Molecular Weight | 1044.30 |