2497687-47-3

2497687-47-3 structure

Name: Antiproliferative agent-7
Chemical Name: Antiproliferative agent-7
CAS Number: 2497687-47-3
Molecular Formula: C₂₈H₃₂N₄O
Molecular Weight: 440.58
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-02 09:48:33
Modify Date: 2024-01-13 18:47:08
Antiproliferative against-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative against-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative against-7 can increase ROS production and induce apoptosis[1].

Name	Antiproliferative agent-7

Description	Antiproliferative against-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative against-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative against-7 can increase ROS production and induce apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Target	IC50: 3.5 μM (MCF-7), 15.54 μM (MDA-MB-231), 30.43 μM (HCT-116), 34.8 μM (FR-2)[1]
References	[1]. Dheer D,et al.Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents. Eur J Med Chem. 2020 Dec 1;207:112813.

Molecular Formula	C₂₈H₃₂N₄O
Molecular Weight	440.58