2454133-88-9

2454133-88-9 structure

Name: Antitumor agent-70
Chemical Name: Antitumor agent-70
CAS Number: 2454133-88-9
Molecular Formula: C₂₁H₁₈N₄O₂
Molecular Weight: 358.39
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-18 20:45:12
Modify Date: 2024-01-18 10:56:55
Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].

Name	Antitumor agent-70

Description	Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
In Vitro	Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells [1]. Cell Proliferation Assay[1] Cell Line: Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC Concentration: 0-50 μM Incubation Time: 24 hours Result: Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC50 value of 3.81 μM, 0.12 μM, 12.09 μM respectively. Cell Cycle Analysis[1] Cell Line: RPMI8226 Concentration: 0-0.2 μM Incubation Time: 24 hours Result: Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly. Apoptosis Analysis[1] Cell Line: RPMI8226 Concentration: 0-0.2 μM Incubation Time: 24 hours Result: Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.
References	[1]. Xin-Yang Li, et al. Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Oct;103:104189.

Molecular Formula	C₂₁H₁₈N₄O₂
Molecular Weight	358.39

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2454133-88-9	2396562-55-1
2456288-82-5	2460735-29-7
1627600-90-1	2456288-81-4
2371727-65-8	2758520-84-0
2409952-04-9	865784-65-2
1118787-91-9	1118787-95-3
1114824-14-4	1170637-69-0
1118788-30-9	1172485-75-4
1118787-05-5	1118787-06-6
1118787-09-9	1087789-17-0