Antitumor agent-70

Modify Date: 2024-01-18 10:56:55

Antitumor agent-70 structure	Common Name	Antitumor agent-70
	CAS Number	2454133-88-9	Molecular Weight	358.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₈N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antitumor agent-70

Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].

Name	Antitumor agent-70

Description	Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit
In Vitro	Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells [1]. Cell Proliferation Assay[1] Cell Line: Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC Concentration: 0-50 μM Incubation Time: 24 hours Result: Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC50 value of 3.81 μM, 0.12 μM, 12.09 μM respectively. Cell Cycle Analysis[1] Cell Line: RPMI8226 Concentration: 0-0.2 μM Incubation Time: 24 hours Result: Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly. Apoptosis Analysis[1] Cell Line: RPMI8226 Concentration: 0-0.2 μM Incubation Time: 24 hours Result: Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.
References	[1]. Xin-Yang Li, et al. Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Oct;103:104189.

Molecular Formula	C₂₁H₁₈N₄O₂
Molecular Weight	358.39

Antitumor agent-70

Use of Antitumor agent-70

Names

Antitumor agent-70 Biological Activity

Chemical & Physical Properties