FGFR-IN-8
Modify Date: 2025-09-06 20:11:54
FGFR-IN-8 structure
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Common Name | FGFR-IN-8 | ||
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| CAS Number | 2640217-64-5 | Molecular Weight | 584.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H31Cl2N9O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FGFR-IN-8FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1]. |
| Name | FGFR-IN-8 |
|---|
| Description | FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1, V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4, respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities[1]. |
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| Related Catalog | |
| Target |
FGFR1:<0.5 nM (IC50) V564F-FGFR2:189.1 nM (IC50) N549H-FGFR2:<0.5 nM (IC50) V555M-FGFR3:22.6 nM (IC50) FGFR3:<0.5 nM (IC50) FGFR4:7.30 nM (IC50) V561M-FGFR1:262.5 nM (IC50) K650E-FGFR3:<0.5 nM (IC50) K650M-FGFR3:4.8 nM (IC50) |
| References |
| Molecular Formula | C27H31Cl2N9O2 |
|---|---|
| Molecular Weight | 584.50 |