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66-84-2

66-84-2 structure
66-84-2 structure
  • Name: D-Glucosamine hydrochloride
  • Chemical Name: D-Glucosamine hydrochloride
  • CAS Number: 66-84-2
  • Molecular Formula: C6H14ClNO5
  • Molecular Weight: 215.632
  • Catalog: API Antipyretic analgesics Anti-gout medicine
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-01 22:39:22
  • Glucosamine (hydrochloride) is a natural product.IC50 value:Target:In vitro: Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity [1]. Short-term (4 h) glucosamine hydrochloride treatment inhibited HIF-1α at the protein level, decreased phosphorylation of p70S6K and S6, translation-related proteins [2]. In the obstructed kidneys and TGF-β1-treated renal cells, glucosamine hydrochloride significantly decreased renal expression of α-smooth muscle actin, collagen I, and fibronectin [3]. In vivo:

Name D-Glucosamine hydrochloride
Synonyms EINECS 200-638-1
MFCD00135831
Glucopyranose, 2-amino-2-deoxy-, hydrochloride, D-
Glucosamine (hydrochloride)
Description Glucosamine (hydrochloride) is a natural product.IC50 value:Target:In vitro: Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity [1]. Short-term (4 h) glucosamine hydrochloride treatment inhibited HIF-1α at the protein level, decreased phosphorylation of p70S6K and S6, translation-related proteins [2]. In the obstructed kidneys and TGF-β1-treated renal cells, glucosamine hydrochloride significantly decreased renal expression of α-smooth muscle actin, collagen I, and fibronectin [3]. In vivo:
Related Catalog
References

[1]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

[2]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

[3]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.

Boiling Point 449.9ºC at 760 mmHg
Melting Point 190-194ºC
Molecular Formula C6H14ClNO5
Molecular Weight 215.632
Flash Point 225.9ºC
Exact Mass 215.056046
PSA 124.01000
Index of Refraction 72 ° (C=1, H2O)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ6665000
CHEMICAL NAME :
D-Glucose, 2-amino-2-deoxy-, hydrochloride
CAS REGISTRY NUMBER :
66-84-2
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H13-N-O5.Cl-H
MOLECULAR WEIGHT :
215.66
WISWESSER LINE NOTATION :
VHYZYQYQYQ1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve

MUTATION DATA

TEST SYSTEM :
Fish - not otherwise specified
DOSE/DURATION :
1000 ppm
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 28,176,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2043 No. of Facilities: 1651 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 16143 (estimated) No. of Female Employees: 13164 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F: Flammable;Xi: Irritant;Xn: Harmful;
Risk Phrases R21
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS LZ6665000
HS Code 2932999099

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Detail
Literature: Phytochemistry, , vol. 71, # 11-12 p. 1375 - 1380

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66-84-2 structure

66-84-2

Literature: European Journal of Pharmacology, , vol. 579, # 1-3 p. 74 - 85

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66-84-2 structure

66-84-2

Literature: Journal of the Chemical Society, , p. 81,85
HS Code 2922399090
Summary 2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%