Anti-gout medicine

Gout is a disease based on abnormal sputum metabolism and uric acid excretion, which is based on hyperuricemia. It is characterized by the deposition of sodium urate needle crystals in tissues, recurrent episodes of typical acute arthritis and kidney disease. Sexual disease. Although it is considered to be a disease of rich life, most of the cockroaches in the body are synthesized in the body, so the food cockroaches have not paid much attention in the past. Anti-gout drugs are now divided into two categories. (1) Anti-inflammatory analgesics In addition to indomethacin (indomethacin) and phenylbutazone, colchicine is also a special anti-gout drug. Colchicine is found in the seeds or bulbs of the genus Syzygium, a lily plant, which has been used since ancient times in Egypt and Greece. The mechanism of action is still unclear. It is believed that it may directly block the uric acid phagocytosis of leukocytes, or stabilize the lysosomes acting on leukocytes, and cut off the cycle between uric acid crystal precipitation and inflammation. (2) Xanthine oxidase inhibitor Allopurinol is synthesized in the process of studying anticancer drugs. RW Rundles et al found that it became a substrate for xanthine oxidase in the test tube, and it is also an inhibitor, which can inhibit the chanting. The step of oxidation reaction to produce uric acid has an inhibitory effect on each step of the reaction. In 1963, JB Wyngaarden conducted a clinical trial of allopurinol in London and reported that it can be used to correct hyperuricemia. (3) Urinary acid excretion agent 1 thiazolone (benzenesulfazolone) The trade name of Ciba-Geigy is Anturane. This product has the effect of inhibiting the reabsorption of uric acid by renal tubules. It is a pyrazolone anti-gout drug found in the elimination of the side effects of phenylbutazone. 2 probenecid (carboxybenzene sulfonamide) This product also has the effect of inhibiting renal tubular reabsorption of uric acid. 3 benzbromarone (bromophenone)