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Related CAS#:
482-38-2 4607-38-9
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482-38-2

482-38-2 structure
482-38-2 structure
  • Name: Kaempferitrin
  • Chemical Name: kaempferol 3-O-α-L-rhamnopyranosyl-7-O-α-L-rhamnopyranoside
  • CAS Number: 482-38-2
  • Molecular Formula: C27H30O14
  • Molecular Weight: 578.519
  • Catalog: Natural product Flavonoids
  • Create Date: 2018-02-19 08:00:00
  • Modify Date: 2024-01-05 16:54:39
  • Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
Name kaempferol 3-O-α-L-rhamnopyranosyl-7-O-α-L-rhamnopyranoside
Synonyms kaempferol 3-O-alpha-L-rhamnopyranosyl-7-O-alpha-L-rhamnopyranoside
4H-1-Benzopyran-4-one, 3,7-bis[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl 6-deoxy-α-L-mannopyranoside
kaempferol 3,7-di-O-α-L-rhamnoside
5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]chromen-4-one
Kaempferol 3,7-L-dirhamnoside
Kaemferitrin
Kaempferol 3,7-dirhamnoside
lespenefril
kaempferol-3,7-O-α-L-dirhamnoside
Lespenephryl
Kaempferol-3,7-O-bis-α-L-rhamnoside
Kaempferitrin
Kaempferol 3,7-bisrhamnoside
Lespedin
Description Kaempferitrin is a natural flavonoid, possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral and chemopreventive effects, and activates insulin signaling pathway.
Related Catalog
Target

Insulin Receptor[1]

In Vitro Kaempferitrin activates insulin signaling pathway. Kaempferitrin causes survival rates higher than 90% at 1-20 μM in matured 3T3-L1 adipocyte, and the survival rates decline rapidly at 25 and 50 μM. Kaempferitrin (15 μM) increases insulin receptor beta tyrosine phosphorylation and tyrosine phosphorylation of the insulin receptor substrate 1, and such effects are similar to that of 10 nM insulin. Kaempferitrin (15 μM) also stimulates akt phosphorylation on ser473, and the stimulation can be blocked by a PI3-K inhibitor wortmannin. Kaempferitrin potently exerts the translocation of GLUT4 to the membrane of adipocytes at 15 μM, and this is suppressed by wortmannin. In addition, Kaempferitrin increases the total levels of Glu4 protein in differentiated cells and secreted adiponectin in mature 3T3-L1 adipocytes[1]. Kaempferitrin is cytotoxic to human cancer cells such as HeLa and MDA-MB231 cells, with IC50s of 45 ± 2.6 and 65 ± 2.6 μM, and shows low toxic effects on non-tumorigenic cells. Kaempferitrin (45 μM) induces apoptosis of HeLa cells after treatment for 24 and 48 h, and causes reactive oxygen species (ROS) generation in HeLa cells. Furthermore, Kaempferitrin (45 μM) exerts G1 arrest, causes the expression of proteins associated with intrinsic pathway of apoptosis and activates caspase 3 in HeLa cells[2].
In Vivo Kaempferitrin (2.5, 10 and 25 mg/kg, i.p.) markedly suppresses the growth of tumor by 40%, 87% and 97%, and decreases tumor weight by 37%, 81% and 95%, respectively in nu/nu mice bearing HeLa tumor. Kaempferitrin also inhibits cell proliferation and extends life span in mice bearing tumor[2].
Cell Assay Viability assay is carried out by MTT assay. Preconfluent 3T3-L1 preadipocytes are seeded to reach confluence. Kaempferitrin is added in replacement of insulin immediately after confluence (day 0), and the viability is measured 3 h after addition of the compound. Another cell viability assay is performed at day 8. For kaempferitrin combined with insulin treatment, various concentrations of kaempferitrin are added simultaneously with 0.2 nM insulin from day 0 to day 8. Cells without insulin or kaempferitrin treatment during differentiation (day 0 to day 8) are used as control. Finally, to verify the cell viability in matured 3T3-L1 cells treated with insulin or kaempferitrin for 24-48 h, MTT are incubated for 3 h at the end of the 24 h and 48 h period of compound treatments, and survival rates calculated and compared to that without insulin or kaempferitrin[1].
Animal Admin The nu/nu mice are injected subcutaneously in their backs with HeLa cells (1.5 × 106). Four hours after tumor implantation, groups of five mice receive doses of Kaempferitrin between 2.5 to 25 mg/kg, dissolved in 0.1 mL of 0.9% saline solution, cisplatin (CDDP) 1 mg/kg or paclitaxel (PCX) 1 mg/kg injected intraperitoneally daily over a period of 32 days. The animal control group received 0.1 mL of vehicle solution. Tumors are measured using a vernier caliper, and their size in mm3 is calculated Tumor volume = lenght × width × height2. At the end of the experiments, animals are sacrificed and their tumors are excised and weighed[2].
References

[1]. Tzeng YM, et al. Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes. Eur J Pharmacol. 2009 Apr 1;607(1-3):27-34.

[2]. Alonso-Castro AJ, et al. Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol. 2013 Jan 30;145(2):476-89.
Density 1.7±0.1 g/cm3
Boiling Point 908.6±65.0 °C at 760 mmHg
Molecular Formula C27H30O14
Molecular Weight 578.519
Flash Point 302.8±27.8 °C
Exact Mass 578.163574
PSA 228.97000
LogP 1.66
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.725
Storage condition -20C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ2977500
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 3,7-bis((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydrox y-2-(4- hydroxyphenyl)-
CAS REGISTRY NUMBER :
482-38-2
BEILSTEIN REFERENCE NO. :
0073958
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C27-H30-O14
MOLECULAR WEIGHT :
578.57
WISWESSER LINE NOTATION :
T66 BO EVJ CR DQ& DO- BT6OTJ CQ DQ EQ F1& IO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
20 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981
Safety Phrases 24/25

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