HE 3286
Modify Date: 2025-08-25 07:48:38
HE 3286 structure
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Common Name | HE 3286 | ||
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| CAS Number | 1001100-69-1 | Molecular Weight | 330.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H30O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HE 3286HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor [1][2]. |
| Name | 17α-ethynylandrost-5-ene-3β,7β,17β-triol |
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| Synonym | More Synonyms |
| Description | HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor [1][2]. |
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| Related Catalog | |
| In Vitro | HE3286 attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/ml; 0-2 hours) murine macrophages [3]. HE3286 (100 nM, overnight) partially, but significantly, blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/ml; 0-2 hours) murine macrophages[3]. Western Blot Analysis[3] Cell Line: LPS-induced murine macrophages Concentration: 100 nM Incubation Time: overnight Result: Attenuated NF-κB phosphorylation. Blocked the activation of IKK, JNK, p38, and ERK partially, but significantly. |
| In Vivo | HE3286 (80 mg/kg; 0-24h) freely penetrates the BBB in male CD-1 mice[4]. HE3286 (40 mg/kg; gavage; twice-daily for 4 days) increases the numbers of tyrosine hydroxylase-positive cells and decreases the numbers of damaged neurons in PD mice [4]. HE3286 (40 mg/kg; intraperitoneal injection; daily for 40 days) suppresses inflammation, reduces demyelination and axonal loss, and promotes RGC survival during experimental optic neuritis of EAE mice [2]. HE3286 (25-50 mg/kg; oral gavage; daily for 22-49 days) reduces joint inflammation, synovial proliferation, and erosion of DBA/1 Lac male CIA mice [1]. |
| References |
| Molecular Formula | C21H30O3 |
|---|---|
| Molecular Weight | 330.46 |
| Exact Mass | 330.21900 |
| PSA | 60.69000 |
| LogP | 2.64520 |
| 17α-ethynyl-5-androstene-3β,7β,17β-triol |
| 17α-ethynyl-androst-5-ene-3β,7β,17β-triol |
| HE 3286 |