p-Hydroxymandelic acid

Modify Date: 2024-01-02 14:09:44

p-Hydroxymandelic acid Structure
p-Hydroxymandelic acid structure
Common Name p-Hydroxymandelic acid
CAS Number 1198-84-1 Molecular Weight 168.14700
Density 1.48 g/cm3 Boiling Point 405.4ºC at 760 mmHg
Molecular Formula C8H8O4 Melting Point 82-85 °C(lit.)
MSDS N/A Flash Point 213.1ºC

 Use of p-Hydroxymandelic acid


p-Hydroxymandelic acid is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives.

 Names

Name 4-hydroxymandelic acid
Synonym More Synonyms

 p-Hydroxymandelic acid Biological Activity

Description p-Hydroxymandelic acid is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro p-Hydroxymandelic acid (4-Hydroxymandelic acid; 4-HMA) is widely used in production of aromatic drugs and flavors. It is employed for the preparation of 4-hydroxyphenylacetic acid, which is the synthetic precursor of selective β1-receptor antagonist drug atenolol. p-Hydroxymandelic acid can conjugate cytotoxic drug and enzyme substrate, and such a p-Hydroxymandelic acid based adaptor system showed promising application in the targeting drug delivery system[1].
References

[1]. Li FF, et al. Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose-xylosemixture. Microb Cell Fact. 2016 May 27;15:90.

 Chemical & Physical Properties

Density 1.48 g/cm3
Boiling Point 405.4ºC at 760 mmHg
Melting Point 82-85 °C(lit.)
Molecular Formula C8H8O4
Molecular Weight 168.14700
Flash Point 213.1ºC
Exact Mass 168.04200
PSA 77.76000
LogP 0.51020
Storage condition -20°C

 MSDS

Name: DL-4-Hydroxymandelic acid 95% Material Safety Data Sheet
Synonym: alpha,4-Dihydroxybenzeneacetic acid; DL-4-Hydroxymandelic acid; DL-p-Hydroxymandelic acid; p-Hydroxyphenylglycolic acid
CAS: 1198-84-1
Section 1 - Chemical Product MSDS Name:DL-4-Hydroxymandelic acid 95% Material Safety Data Sheet
Synonym:alpha,4-Dihydroxybenzeneacetic acid; DL-4-Hydroxymandelic acid; DL-p-Hydroxymandelic acid; p-Hydroxyphenylglycolic acid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1198-84-1 4-Hydroxyphenylglycolic acid 95 214-839-7
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing dust.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1198-84-1: CAS# 7198-10-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: off-white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 103-106 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H8O4
Molecular Weight: 168.15

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Darkens and decomposes on exposure to light.
Conditions to Avoid:
Dust generation, excess heat, excess light.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1198-84-1 unlisted.
CAS# 7198-10-9 unlisted.
LD50/LC50:
Not available.
Not available.
Carcinogenicity:
4-Hydroxyphenylglycolic acid - Not listed by ACGIH, IARC, or NTP.
Deleted Registry Number - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1198-84-1: No information available.
CAS# 7198-10-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1198-84-1 is not listed on Canada's Ingredient Disclosure List.
CAS# 7198-10-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1198-84-1 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 7198-10-9 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
WGK Germany 3
HS Code 2918290000

 Synthetic Route

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Synonyms

EINECS 214-839-7
4-Hydroxyphenylglycolic Acid
P-Hydroxy Mandelic Acid
2-Hydroxy-2-(4-hydroxyphenyl)acetic acid
MFCD00004234
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