PF-4778574

Modify Date: 2024-01-22 17:00:49

PF-4778574 Structure
PF-4778574 structure
Common Name PF-4778574
CAS Number 1219633-99-4 Molecular Weight 390.52000
Density N/A Boiling Point N/A
Molecular Formula C19H22N2O3S2 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of PF-4778574


PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.

 Names

Name N-{(3R,4S)-3-[4-(5-Cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-y l}-2-propanesulfonamide

 PF-4778574 Biological Activity

Description PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
Related Catalog
Target

EC50: 45 to 919 nM (AMPAR)[1]

References

[1]. Shaffer, C.L.; Scialis, R.J.; Lotarski, S.; et al. Defining themechanism-mediated exposure-response continuum of a novelAMPA receptor potentiator. 39th Annu Meet Soc Neurosci (October17-21, Chicago) 2009, Abst 883.17

 Chemical & Physical Properties

Molecular Formula C19H22N2O3S2
Molecular Weight 390.52000
Exact Mass 390.10700
PSA 115.81000
LogP 4.95878

 Safety Information

RIDADR NONH for all modes of transport
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