Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Modify Date: 2024-01-16 18:03:34

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate structure	Common Name	Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
	CAS Number	132465-11-3	Molecular Weight	321.32700
	Density	1.326 g/cm3	Boiling Point	583.9ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₅NO₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	307ºC
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus[1].

Name	cdc

Description	Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Metabolic Disease
In Vitro	High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport[1].
In Vivo	The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions[1].
References	[1]. Wang X, et al. 12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury. J Diabetes Investig. 2019;10(3):639-649.

Density	1.326 g/cm3
Boiling Point	583.9ºC at 760 mmHg
Molecular Formula	C₁₉H₁₅NO₄
Molecular Weight	321.32700
Flash Point	307ºC
Exact Mass	321.10000
PSA	90.55000
LogP	3.26138
Storage condition	-20°C

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H317-H410
Precautionary Statements	P273-P280-P501
Hazard Codes	Xi
Risk Phrases	43-50/53
Safety Phrases	36/37-60-61
RIDADR	UN 3077 9 / PGIII

Precursor 1
CAS#:139-85-5 3,4-Dihydroxybe...
DownStream 0

DC Chemicals Limited
China
Product Name: CDC 5-LO inhibitor
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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Price: ￥4500/5 mg

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Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

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Precursor & DownStream