Bis-PEG7-PFP ester

Modify Date: 2024-01-09 18:24:39

Bis-PEG7-PFP ester Structure
Bis-PEG7-PFP ester structure
Common Name Bis-PEG7-PFP ester
CAS Number 1334170-01-2 Molecular Weight 758.552
Density 1.4±0.1 g/cm3 Boiling Point 664.2±55.0 °C at 760 mmHg
Molecular Formula C30H32F10O11 Melting Point N/A
MSDS N/A Flash Point 342.1±26.4 °C

 Use of Bis-PEG7-PFP ester


Bis-PEG7-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bis(pentafluorophenyl) 4,7,10,13,16,19,22-heptaoxapentacosane-1,25-dioate
Synonym More Synonyms

 Bis-PEG7-PFP ester Biological Activity

Description Bis-PEG7-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 664.2±55.0 °C at 760 mmHg
Molecular Formula C30H32F10O11
Molecular Weight 758.552
Flash Point 342.1±26.4 °C
Exact Mass 758.178467
LogP 2.84
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.465

 Synonyms

4,7,10,13,16,19,22-Heptaoxapentacosane-1,25-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester
Bis(pentafluorophenyl) 4,7,10,13,16,19,22-heptaoxapentacosane-1,25-dioate
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