Bis-methacrylate-PEG5

Modify Date: 2024-01-02 17:50:03

Bis-methacrylate-PEG5 Structure
Bis-methacrylate-PEG5 structure
Common Name Bis-methacrylate-PEG5
CAS Number 13497-24-0 Molecular Weight 374.42600
Density N/A Boiling Point N/A
Molecular Formula C18H30O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bis-methacrylate-PEG5


Bis-methacrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tetraethyleneglycol dimethacrylate
Synonym More Synonyms

 Bis-methacrylate-PEG5 Biological Activity

Description Bis-methacrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C18H30O8
Molecular Weight 374.42600
Exact Mass 374.19400
PSA 89.52000
LogP 1.29140

 Synonyms

pentaethylene glycol dimethacrylate