Bis-PEG5-NHS ester

Modify Date: 2024-01-10 15:40:58

Bis-PEG5-NHS ester Structure
Bis-PEG5-NHS ester structure
Common Name Bis-PEG5-NHS ester
CAS Number 756526-03-1 Molecular Weight 532.49500
Density N/A Boiling Point N/A
Molecular Formula C22H32N2O13 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Bis-PEG5-NHS ester


Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Synonym More Synonyms

 Bis-PEG5-NHS ester Biological Activity

Description Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.

 Chemical & Physical Properties

Molecular Formula C22H32N2O13
Molecular Weight 532.49500
Exact Mass 532.19000
PSA 173.51000

 Synonyms

Bis-PEG5-NHS ester
AmbotzPEG1435
BIS-SUCCINIMIDYL-4,7,10,13,16-PENTAOXANONADECANE-1,19-DIOATE
B3728
Bis-dPEG5-NHS ester
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