Betazole dihydrochloride

Modify Date: 2024-01-06 19:25:22

Betazole dihydrochloride structure	Common Name	Betazole dihydrochloride
	CAS Number	138-92-1	Molecular Weight	184.06700
	Density	N/A	Boiling Point	284.1ºC at 760mmHg
	Molecular Formula	C₅H₁₁Cl₂N₃	Melting Point	224-226°
	MSDS	N/A	Flash Point	150.3ºC

Use of Betazole dihydrochloride

Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

Name	betazole dihydrochloride
Synonym	More Synonyms

Description	Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor
In Vitro	Betazole (Ametazole) dihydrochloride is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole dihydrochloride induces gastric inhibitory polypeptide (GIP) secretion[1].
References	[1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

Boiling Point	284.1ºC at 760mmHg
Melting Point	224-226°
Molecular Formula	C₅H₁₁Cl₂N₃
Molecular Weight	184.06700
Flash Point	150.3ºC
Exact Mass	183.03300
PSA	54.70000
LogP	2.21520
Vapour Pressure	0.00303mmHg at 25°C
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ5600000

CHEMICAL NAME :: Pyrazole, 3-(2-aminoethyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 138-92-1

LAST UPDATED :: 199404

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H9-N3.2Cl-H

MOLECULAR WEIGHT :: 184.09

WISWESSER LINE NOTATION :: T5MNJ C2Z &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 740 ug/kg/37D-I

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human)

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,275,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 86 ug/kg/6D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,274,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 803 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83995 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)

Hazard Codes	Xn
RIDADR	NONH for all modes of transport
HS Code	2933199090

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1h-pyrazole-3-ethanamine,dihydrochloride

BETAZOLE HYDROCHLORIDE (200 MG)

3-(2-aminoethyl)-pyrazoldihydrochloride

histalog

[2-(1H-Pyrazol-3-yl)ethyl]amine dihydrochloride

ametazoledihydrochloride

Betazole hydrochloride

2-(1(2)H-pyrazol-3-yl)-ethylamine,dihydrochloride

gastramine

2-(1(2)H-Pyrazol-3-yl)-aethylamin,Dihydrochlorid

3-(2-aminoethyl)pyrazole,dihydrochloride

Histimin

DC Chemicals Limited
China
Product Name: Betazole dihydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: betazole dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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