L-(+)Sodium glutamate
Modify Date: 2026-06-30 08:16:00
L-(+)Sodium glutamate structure
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Common Name | L-(+)Sodium glutamate | ||
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| CAS Number | 142-47-2 | Molecular Weight | 169.111 | |
| Density | N/A | Boiling Point | 333.8ºC at 760 mmHg | |
| Molecular Formula | C5H8NNaO4 | Melting Point | 232°C | |
| MSDS | Chinese USA | Flash Point | 155.7ºC | |
Use of L-(+)Sodium glutamateL-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | monosodium L-glutamate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. |
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| Related Catalog | |
| Target |
mGlu1 receptor[1] |
| In Vivo | A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only <20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1]. |
| Animal Admin | For toxicity experiments, mice at PND9 (n=3-9 mice per group) are treated as follows. Two groups receive a subcutaneous (s.c.) injection of corn oil, following, 30 min later, by s.c. injection of either saline or L-Glutamic acid monosodium salt (3 g/kg); two additional groups are treated with 3,4-dihydro-2 H-pyrano[2,3-b]quinolin-7-yl-(cis-4-methoxycyclohexyl)-methanone, dissolving in corn oil (2.5 mg/kg) following, 30 min later, by a s.c. injection of either saline or L-Glutamic acid monosodium salt. In another set of experiments, four groups of crv4 mice or their wild-type littermates (n=5-7 mice per group) are injected s.c. with either saline or L-Glutamic acid monosodium salt (3 g/kg)[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 333.8ºC at 760 mmHg |
|---|---|
| Melting Point | 232°C |
| Molecular Formula | C5H8NNaO4 |
| Molecular Weight | 169.111 |
| Flash Point | 155.7ºC |
| Exact Mass | 169.035110 |
| PSA | 103.45000 |
| Vapour Pressure | 2.55E-05mmHg at 25°C |
| Index of Refraction | 25 ° (C=10, 2mol/L HCl) |
| InChIKey | LPUQAYUQRXPFSQ-DFWYDOINSA-M |
| SMILES | NC(CCC(=O)[O-])C(=O)O.[Na+] |
| Water Solubility | >=10 g/100 mL at 20 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~%
L-(+)Sodium glu... CAS#:142-47-2 |
| Literature: US2004/225133 A1, ; Page 7-8 ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 10 | |
CAS#:3397-65-7
CAS#:3081-61-6
CAS#:1955-67-5
CAS#:56-86-0
CAS#:2746-34-1
CAS#:28874-51-3
CAS#:23356-96-9
CAS#:17342-08-4
CAS#:636-58-8This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas...
Source: Broad Institute
Target: N/A
External Id: 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima...
Source: NCGC
Target: apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7]
External Id: AMA1100
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: abhydrolase domain-containing protein 4 isoform 1 [Mus musculus]
External Id: ABHD4_INH_FP_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MSG |
| MFCD00013074 |
| Glutamate monosodium salt |
| L-GLUTAMIC ACID SODIUM SALT |
| monosodium-l-glutamate |
| Sodium (2S)-2-ammoniopentanedioate |
| L-(+)Sodium Glutamate |
| L-Glutamic acid monosodium salt |
| (S)-2-Aminopentanedioic acid,L-Glutamic acid monosodium salt,Glu |
| L-Sodium glutamate hydrate |
| Monosodium glutamate |
| sodium L-glutamate |
| EINECS 205-538-1 |
| L-Glutamic acid, sodium salt |
| L-Glutamic acid monosodium salt hydrate |
| Glutamic acid sodium salt |
| sodium glutamate |
| Glutamic acid, monosodium salt |
| L-Glutamic acid, monosodium salt |
| L-Glutamic acid, sodium salt (1:1) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of monosodium L-glutamate? |
| A: Molecular weight of monosodium L-glutamate is 169.111. |
| Q: How is the water solubility of monosodium L-glutamate? |
| A: Water solubility of monosodium L-glutamate: >=10 g/100 mL at 20 ºC. |
| Q: What is the polar surface area (PSA) of monosodium L-glutamate? |
| A: Polar surface area (PSA) of monosodium L-glutamate is 103.45000. |
| Q: What is the boiling point of monosodium L-glutamate? |
| A: Boiling point of monosodium L-glutamate is 333.8ºC at 760 mmHg. |
| Q: What is the InChIKey of monosodium L-glutamate? |
| A: InChIKey of monosodium L-glutamate is LPUQAYUQRXPFSQ-DFWYDOINSA-M. |
| Q: What is the CAS number of monosodium L-glutamate? |
| A: CAS number of monosodium L-glutamate is 142-47-2. |
| Q: What is the melting point of monosodium L-glutamate? |
| A: Melting point of monosodium L-glutamate is 232°C. |
| Q: What is the English name of monosodium L-glutamate? |
| A: The English name of monosodium L-glutamate is monosodium L-glutamate. |
| Q: What is the SMILES notation of monosodium L-glutamate? |
| A: SMILES notation of monosodium L-glutamate is NC(CCC(=O)[O-])C(=O)O.[Na+]. |
| Q: What are the downstream products of monosodium L-glutamate? |
| A: Related downstream products(CAS) of monosodium L-glutamate: 3397-65-7;3081-61-6;1955-67-5;56-86-0;2746-34-1;98-79-3;28874-51-3;23356-96-9;17342-08-4;636-58-8. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |