L-(+)Sodium glutamate structure
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Common Name | L-(+)Sodium glutamate | ||
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| CAS Number | 142-47-2 | Molecular Weight | 169.111 | |
| Density | N/A | Boiling Point | 333.8ºC at 760 mmHg | |
| Molecular Formula | C5H8NNaO4 | Melting Point | 232°C | |
| MSDS | Chinese USA | Flash Point | 155.7ºC | |
Use of L-(+)Sodium glutamateL-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. |
| Name | monosodium L-glutamate |
|---|---|
| Synonym | More Synonyms |
| Description | L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. |
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| Related Catalog | |
| Target |
mGlu1 receptor[1] |
| In Vivo | A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only <20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1]. |
| Animal Admin | For toxicity experiments, mice at PND9 (n=3-9 mice per group) are treated as follows. Two groups receive a subcutaneous (s.c.) injection of corn oil, following, 30 min later, by s.c. injection of either saline or L-Glutamic acid monosodium salt (3 g/kg); two additional groups are treated with 3,4-dihydro-2 H-pyrano[2,3-b]quinolin-7-yl-(cis-4-methoxycyclohexyl)-methanone, dissolving in corn oil (2.5 mg/kg) following, 30 min later, by a s.c. injection of either saline or L-Glutamic acid monosodium salt. In another set of experiments, four groups of crv4 mice or their wild-type littermates (n=5-7 mice per group) are injected s.c. with either saline or L-Glutamic acid monosodium salt (3 g/kg)[1]. |
| References |
| Boiling Point | 333.8ºC at 760 mmHg |
|---|---|
| Melting Point | 232°C |
| Molecular Formula | C5H8NNaO4 |
| Molecular Weight | 169.111 |
| Flash Point | 155.7ºC |
| Exact Mass | 169.035110 |
| PSA | 103.45000 |
| Vapour Pressure | 2.55E-05mmHg at 25°C |
| Index of Refraction | 25 ° (C=10, 2mol/L HCl) |
| InChIKey | LPUQAYUQRXPFSQ-DFWYDOINSA-M |
| SMILES | NC(CCC(=O)[O-])C(=O)O.[Na+] |
| Water Solubility | >=10 g/100 mL at 20 ºC |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~%
L-(+)Sodium glu... CAS#:142-47-2 |
| Literature: US2004/225133 A1, ; Page 7-8 ; |
| Precursor 1 | |
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| DownStream 10 | |
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas...
Source: Broad Institute
Target: N/A
External Id: 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima...
Source: NCGC
Target: apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7]
External Id: AMA1100
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: abhydrolase domain-containing protein 4 isoform 1 [Mus musculus]
External Id: ABHD4_INH_FP_1536_1X%INH PRUN
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| MSG |
| MFCD00013074 |
| Glutamate monosodium salt |
| L-GLUTAMIC ACID SODIUM SALT |
| monosodium-l-glutamate |
| Sodium (2S)-2-ammoniopentanedioate |
| L-(+)Sodium Glutamate |
| L-Glutamic acid monosodium salt |
| (S)-2-Aminopentanedioic acid,L-Glutamic acid monosodium salt,Glu |
| L-Sodium glutamate hydrate |
| Monosodium glutamate |
| sodium L-glutamate |
| EINECS 205-538-1 |
| L-Glutamic acid, sodium salt |
| L-Glutamic acid monosodium salt hydrate |
| Glutamic acid sodium salt |
| sodium glutamate |
| Glutamic acid, monosodium salt |
| L-Glutamic acid, monosodium salt |
| L-Glutamic acid, sodium salt (1:1) |