L-GlutaMic acid γ-MonohydroxaMate

Modify Date: 2024-01-09 18:46:25

L-GlutaMic acid γ-MonohydroxaMate Structure
L-GlutaMic acid γ-MonohydroxaMate structure
Common Name L-GlutaMic acid γ-MonohydroxaMate
CAS Number 1955-67-5 Molecular Weight 162.14400
Density 1.432g/cm3 Boiling Point 553.6ºC at 760mmHg
Molecular Formula C5H10N2O4 Melting Point N/A
MSDS USA Flash Point 288.6ºC

 Use of L-GlutaMic acid γ-MonohydroxaMate


L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].

 Names

Name glutamine hydroxamate
Synonym More Synonyms

 L-GlutaMic acid γ-MonohydroxaMate Biological Activity

Description L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].
Related Catalog
References

[1]. Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45(4):737-43.

[2]. Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1192-7.

[3]. Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274(37):26617-24.

 Chemical & Physical Properties

Density 1.432g/cm3
Boiling Point 553.6ºC at 760mmHg
Molecular Formula C5H10N2O4
Molecular Weight 162.14400
Flash Point 288.6ºC
Exact Mass 162.06400
PSA 116.14000
LogP 0.22450
Vapour Pressure 1.46E-14mmHg at 25°C
Index of Refraction 1.538
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2928000090

 Synthetic Route

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L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Yamamoto, Sachiko; Wakayama, Mamoru; Tachiki, Takashi Bioscience, Biotechnology and Biochemistry, 2007 , vol. 71, # 2 p. 545 - 552

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L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Imaoka, Masashi; Yano, Shigekazu; Okumura, Masashi; Hibi, Takao; Wakayama, Mamoru Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 9 p. 1936 - 1939

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L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Roper; McIlwain Biochemical Journal, 1948 , vol. 42, p. 488

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L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Magnan, Sanne D. J.; Shirota, Frances N.; Nagasawa, Herbert T. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1018 - 1021

~%

L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Roper; McIlwain Biochemical Journal, 1948 , vol. 42, p. 488

~%

L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Imaoka, Masashi; Yano, Shigekazu; Okumura, Masashi; Hibi, Takao; Wakayama, Mamoru Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 9 p. 1936 - 1939

~%

L-GlutaMic acid γ-MonohydroxaMate Structure

L-GlutaMic acid...

CAS#:1955-67-5

Literature: Tachiki, Takashi; Yamada, Takeshi; Mizuno, Katsushige; Ueda, Masashi; Shiode, Ju-Ichi; Fukami, Hiroshi Bioscience, Biotechnology and Biochemistry, 1998 , vol. 62, # 7 p. 1279 - 1283

 Customs

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Alternative substrates for wild-type and L109A E. coli CTP synthases: kinetic evidence for a constricted ammonia tunnel.

Eur. J. Biochem. 271(21) , 4204-12, (2004)

Cytidine 5'-triphosphate (CTP) synthase catalyses the ATP-dependent formation of CTP from uridine 5'-triphosphate using either NH(3) or l-glutamine as the nitrogen source. The hydrolysis of glutamine ...

Effect of epidermal growth factor on glutamine metabolic enzymes in small intestine and skeletal muscle of parenterally fed rats.

Nutrition 13(7-8) , 652-5, (1997)

Exogenous epidermal growth factor (EGF) markedly increases the in vivo uptake of glutamine by small intestine during total parenteral nutrition (TPN). Since glutamine is the major oxidative fuel for t...

 Synonyms

(4S)-4-Amino-4-carboxybutanehydroxamic acid
(2S)-5-amino-2-(hydroxyamino)-5-keto-valeric acid
N5-Hydroxy-L-glutamine
(S)-4-Amino-4-carboxybutanehydroximic acid
3-[2-Oxo-2-(hydroxyamino)ethyl]alanine
(2S)-2-Amino-5-oxo-5-(hydroxyamino)pentanoic acid
AMINO ACID HYDROXAMATES L-GLUTAMIC ACID γ-MONOHYDROXAMATE
L-GlutaMic acid γ-MonohydroxaMate