endo-BCN-PEG2-PFP ester

Modify Date: 2024-01-02 18:32:04

endo-BCN-PEG2-PFP ester Structure
endo-BCN-PEG2-PFP ester structure
Common Name endo-BCN-PEG2-PFP ester
CAS Number 1421932-53-7 Molecular Weight 519.458
Density 1.4±0.1 g/cm3 Boiling Point 586.2±50.0 °C at 760 mmHg
Molecular Formula C24H26F5NO6 Melting Point N/A
MSDS N/A Flash Point 308.3±30.1 °C

 Use of endo-BCN-PEG2-PFP ester


endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Pentafluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oate
Synonym More Synonyms

 endo-BCN-PEG2-PFP ester Biological Activity

Description endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 586.2±50.0 °C at 760 mmHg
Molecular Formula C24H26F5NO6
Molecular Weight 519.458
Flash Point 308.3±30.1 °C
Exact Mass 519.168030
LogP 4.16
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.520

 Synonyms

2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-bicyclo[6.1.0]non-4-yn-9-yl-3-oxo-, 2,3,4,5,6-pentafluorophenyl ester
Pentafluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oate
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