Tos-PEG3-CH2COOtBu

Modify Date: 2024-01-09 17:14:46

Tos-PEG3-CH2COOtBu Structure
Tos-PEG3-CH2COOtBu structure
Common Name Tos-PEG3-CH2COOtBu
CAS Number 1530778-24-5 Molecular Weight 418.502
Density 1.2±0.1 g/cm3 Boiling Point 517.7±45.0 °C at 760 mmHg
Molecular Formula C19H30O8S Melting Point N/A
MSDS N/A Flash Point 266.9±28.7 °C

 Use of Tos-PEG3-CH2COOtBu


Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl {2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}acetate
Synonym More Synonyms

 Tos-PEG3-CH2COOtBu Biological Activity

Description Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 517.7±45.0 °C at 760 mmHg
Molecular Formula C19H30O8S
Molecular Weight 418.502
Flash Point 266.9±28.7 °C
Exact Mass 418.166138
LogP 2.22
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.496

 Synonyms

Acetic acid, 2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl {2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}acetate