Dyrk1A-IN-5
Modify Date: 2025-09-10 20:52:24
Dyrk1A-IN-5 structure
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Common Name | Dyrk1A-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 1685235-41-9 | Molecular Weight | 388.16 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H9IN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dyrk1A-IN-5Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research[1]. |
| Name | Dyrk1A-IN-5 |
|---|
| Description | Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research[1]. |
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| Related Catalog | |
| Target |
DYRK1A:6 nM (IC50) DYRK1B:600 nM (IC50) DYRK2:>10000 nM (IC50) |
| References |
| Molecular Formula | C16H9IN2O2 |
|---|---|
| Molecular Weight | 388.16 |