Fmoc-PEG6-NHS ester

Modify Date: 2024-01-20 13:39:31

Fmoc-PEG6-NHS ester Structure
Fmoc-PEG6-NHS ester structure
Common Name Fmoc-PEG6-NHS ester
CAS Number 1818294-31-3 Molecular Weight 672.719
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C34H44N2O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-PEG6-NHS ester


Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Fmoc-PEG6-NHS ester
Synonym More Synonyms

 Fmoc-PEG6-NHS ester Biological Activity

Description Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C34H44N2O12
Molecular Weight 672.719
Exact Mass 672.289429
LogP 0.06
Index of Refraction 1.575
Storage condition 2-8°C

 Synonyms

MFCD24539479
9H-Fluoren-9-ylmethyl {21-[(2,5-dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}carbamate
Carbamic acid, N-[21-[(2,5-dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxaheneicos-1-yl]-, 9H-fluoren-9-ylmethyl ester
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