m-PEG6-NHS ester

Modify Date: 2025-08-25 19:29:29

m-PEG6-NHS ester Structure
m-PEG6-NHS ester structure
Common Name m-PEG6-NHS ester
CAS Number 1449390-12-8 Molecular Weight 421.439
Density 1.2±0.1 g/cm3 Boiling Point 502.6±60.0 °C at 760 mmHg
Molecular Formula C18H31NO10 Melting Point N/A
MSDS N/A Flash Point 257.8±32.9 °C

 Use of m-PEG6-NHS ester


m-PEG6-NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name 1-[(20-Oxo-2,5,8,11,14,17-hexaoxaicosan-20-yl)oxy]-2,5-pyrrolidinedione
Synonym More Synonyms

 m-PEG6-NHS ester Biological Activity

Description m-PEG6-NHS ester is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Boehnke, Niels, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 502.6±60.0 °C at 760 mmHg
Molecular Formula C18H31NO10
Molecular Weight 421.439
Flash Point 257.8±32.9 °C
Exact Mass 421.194794
LogP -3.59
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.489

 Safety Information

Hazard Codes Xi

 Synonyms

1-[(20-Oxo-2,5,8,11,14,17-hexaoxaicosan-20-yl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13,16,19-hexaoxaeicos-1-yl)oxy]-
mPEG5-NHS
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