SGC-SMARCA-BRDVIII

Modify Date: 2024-01-10 21:39:24

SGC-SMARCA-BRDVIII structure	Common Name	SGC-SMARCA-BRDVIII
	CAS Number	1997319-84-2	Molecular Weight	371.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₅N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SGC-SMARCA-BRDVIII

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

Name	SGC-SMARCA-BRDVIII

Description	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Kd: 35 nM (SMARCA2), 36 nM (SMARCA4), 13 nM (PB1(5))[1]
In Vitro	SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1].
References	[1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [2]. Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338.

Molecular Formula	C₁₉H₂₅N₅O₃
Molecular Weight	371.43
Storage condition	-20°C

Hazard Codes	Xn

DC Chemicals Limited
China
Product Name: SGC-SMARCA-BRDVIII
Price: $Inquiry/1kg
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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SGC-SMARCA-BRDVIII

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