1997319-84-2

1997319-84-2 structure

Name: SGC-SMARCA-BRDVIII
Chemical Name: SGC-SMARCA-BRDVIII
CAS Number: 1997319-84-2
Molecular Formula: C₁₉H₂₅N₅O₃
Molecular Weight: 371.43
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-03-28 15:14:11
Modify Date: 2024-01-10 21:39:24
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

Name	SGC-SMARCA-BRDVIII

Description	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Kd: 35 nM (SMARCA2), 36 nM (SMARCA4), 13 nM (PB1(5))[1]
In Vitro	SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts[1].
References	[1]. Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63(23):14680-14699. [2]. Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6(33):21327-21338.

Hazard Codes	Xn