Propargyl-PEG3-alcohol
Propargyl-PEG3-alcohol structure
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Common Name | Propargyl-PEG3-alcohol | ||
|---|---|---|---|---|
| CAS Number | 208827-90-1 | Molecular Weight | 188.22100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H16O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Propargyl-PEG3-alcoholPropargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
| Name | 2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Andrew P. Crew, et al. Brm targeting compounds and associated methods of use. US20190300521A1. |
| Molecular Formula | C9H16O4 |
|---|---|
| Molecular Weight | 188.22100 |
| Exact Mass | 188.10500 |
| PSA | 47.92000 |
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~73%
Propargyl-PEG3-... CAS#:208827-90-1 |
| Literature: Wang, Tao; Ng, David Y. W.; Wu, Yuzhou; Thomas, Jessica; Tamtran, Thuy; Weil, Tanja Chemical Communications, 2014 , vol. 50, # 9 p. 1116 - 1118 |
|
~44%
Propargyl-PEG3-... CAS#:208827-90-1 |
| Literature: Baccaro, Anna; Weisbrod, Samuel H.; Marx, Andreas Synthesis, 2007 , # 13 p. 1949 - 1954 |
|
~30%
Propargyl-PEG3-... CAS#:208827-90-1 |
| Literature: Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424 |
|
~%
Propargyl-PEG3-... CAS#:208827-90-1 |
| Literature: Hansen, T. Matthew; Engler, Mary M.; Forsyth, Craig J. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2127 - 2130 |
|
~%
Propargyl-PEG3-... CAS#:208827-90-1 |
| Literature: Hansen, T. Matthew; Engler, Mary M.; Forsyth, Craig J. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2127 - 2130 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| 1-O-propargyl triethylene glycol |