Thalidomide, propargyl

Modify Date: 2024-01-16 08:59:05

Thalidomide, propargyl Structure
Thalidomide, propargyl structure
Common Name Thalidomide, propargyl
CAS Number 2098487-39-7 Molecular Weight 312.27688
Density N/A Boiling Point N/A
Molecular Formula C16H12N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide, propargyl


Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1].

 Names

Name 2-(2,6-dioxopiperidin-3-yl)-4-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

 Thalidomide, propargyl Biological Activity

Description Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1].
Related Catalog
Target

Cereblon

References

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

 Chemical & Physical Properties

Molecular Formula C16H12N2O5
Molecular Weight 312.27688

 Safety Information

Hazard Codes Xi