APJ receptor agonist 4
Modify Date: 2024-01-08 23:11:29
APJ receptor agonist 4 structure
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Common Name | APJ receptor agonist 4 | ||
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| CAS Number | 2135515-67-0 | Molecular Weight | 551.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H28ClFN6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of APJ receptor agonist 4APJ receptor agonist 4 is a potent and oral active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease[1]. |
| Name | APJ receptor agonist 4 |
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| Description | APJ receptor agonist 4 is a potent and oral active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease[1]. |
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| Related Catalog | |
| Target |
apelin receptor[1] |
| In Vivo | Assessment of Pharmacokinetics (PK) profile of APJ receptor agonist 4 (compound 21) in mouse[1]. species rat monkey dogmax (ng/mL) dose (mg/kg) 1 (i.v. and p.o.) 1 (i.v.) and 3 (p.o.) 1 (i.v. and p.o.) vehiclea F G G CI (mL/min/kg) 4.6 10.6 2.4 VSS (L/kg) 1.6 0.2 0.2 T1/2 (h) 4.0 1.3 2.5 Cmax (μM•h) 2.2 1.4 6.5 AUC0-24 (μM•h) 3.7 2.5 14.2 F (%) 54 27 76 a: Vehicle F: 5/5/90 v/v/v DMAC/Cremophor EL/sodium carbonate buffer, pH 9 and vehicle G: 10/40/50 v/v/v ethanol/PEG400/sodium carbonate buffer, pH 9. |
| References |
| Molecular Formula | C28H28ClFN6O3 |
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| Molecular Weight | 551.01 |