PROTAC BRD4 Degrader-5

Modify Date: 2024-01-11 16:22:15

PROTAC BRD4 Degrader-5 Structure
PROTAC BRD4 Degrader-5 structure
Common Name PROTAC BRD4 Degrader-5
CAS Number 2409538-70-9 Molecular Weight 1016.67
Density N/A Boiling Point N/A
Molecular Formula C50H62ClN9O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PROTAC BRD4 Degrader-5


PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

 Names

Name PROTAC BRD4 Degrader-5

 PROTAC BRD4 Degrader-5 Biological Activity

Description PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
Related Catalog
Target

BRD4

In Vitro PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1]. Western Blot Analysis[1] Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells Concentration: 5 nM, 10 nM, 50 nM, 100 nM Incubation Time: 4 hours Result: Degradation of BRD4 in MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cell.
References

[1]. Marı A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.

 Chemical & Physical Properties

Molecular Formula C50H62ClN9O8S2
Molecular Weight 1016.67
Storage condition 2-8°C
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