PROTAC BRD4 Degrader-1
Modify Date: 2024-01-11 08:36:06
PROTAC BRD4 Degrader-1 structure
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Common Name | PROTAC BRD4 Degrader-1 | ||
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| CAS Number | 2133360-00-4 | Molecular Weight | 771.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H37N9O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BRD4 Degrader-1PROTAC BRD4 Degrader-1 is an efficacious BRD4 degrader with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1]. |
| Name | PROTAC BRD4 Degrader-1 |
|---|
| Description | PROTAC BRD4 Degrader-1 is an efficacious BRD4 degrader with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1]. |
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| Related Catalog | |
| Target |
BRD4 (BD1):41.8 nM (IC50) |
| In Vitro | PROTAC BRD4 Degrader-1 (compound 21) (2.5 μM; 24 hours) shows high inhibitory activity against the growth of human monocyte lymphoma cell line THP-1, with the IC50 value of 0.81 μM, and moderate activity against Raji and HL-60 cell lines[1]. PROTAC BRD4 Degrader-1 (1 μM; 24 hours) effectively induces the degradation of BRD4 protein and suppression of c-Myc, while pomalidomide couldn’t degrade BRD4 at the low concentration[1]. Cell Proliferation Assay[1] Cell Line: HL-60, Raji and THP-1 cell Concentration: 2.5 μM Incubation Time: 24 hours Result: Inhibited HL-60, Raji and THP-1 cell growth. Western Blot Analysis[1] Cell Line: THP-1 cell Concentration: 1 μM Incubation Time: 3 hours Result: Degraded BRD4 protein and suppressed c-Myc expression. |
| References |
| Molecular Formula | C40H37N9O8 |
|---|---|
| Molecular Weight | 771.78 |
| Storage condition | 2-8°C |