PROTAC BRD4 Degrader-15

Modify Date: 2024-01-12 12:02:51

PROTAC BRD4 Degrader-15 structure	Common Name	PROTAC BRD4 Degrader-15
	CAS Number	2417370-67-1	Molecular Weight	1149.29
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₇H₆₂F₂N₁₀O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

Name	PROTAC BRD4 Degrader-15

Description	PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD4 BD1:7.2 nM (IC50) BRD4 BD2:8.1 nM (IC50)
In Vitro	PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 15 nM[1]. PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC50 of 4.2 nM and 91 nM[1].
References	[1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

Molecular Formula	C₅₇H₆₂F₂N₁₀O₁₀S₂
Molecular Weight	1149.29
Storage condition	2-8°C

DC Chemicals Limited
China
Product Name: PROTAC BRD4 Degrader-15
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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Chemical & Physical Properties