BnO-PEG6-OH

Modify Date: 2024-01-11 07:01:16

BnO-PEG6-OH Structure
BnO-PEG6-OH structure
Common Name BnO-PEG6-OH
CAS Number 24342-68-5 Molecular Weight 372.453
Density 1.1±0.1 g/cm3 Boiling Point 473.6±40.0 °C at 760 mmHg
Molecular Formula C19H32O7 Melting Point N/A
MSDS N/A Flash Point 240.3±27.3 °C

 Use of BnO-PEG6-OH


BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

 Names

Name 2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 BnO-PEG6-OH Biological Activity

Description BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Shaoyun Xiang, et al. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses there. Patent WO2016197946A1.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 473.6±40.0 °C at 760 mmHg
Molecular Formula C19H32O7
Molecular Weight 372.453
Flash Point 240.3±27.3 °C
Exact Mass 372.214813
PSA 75.61000
LogP -0.54
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.494

 Synthetic Route

~71%

BnO-PEG6-OH Structure

BnO-PEG6-OH

CAS#:24342-68-5

Literature: Gartiser, Thierry; Selve, Claude; Mansuy, Laurence; Robert, Alain; Delpuech, Jean-Jacques Journal of Chemical Research, Miniprint, 1984 , # 9 p. 2672 - 2691

~83%

BnO-PEG6-OH Structure

BnO-PEG6-OH

CAS#:24342-68-5

Literature: Loiseau, Francois A.; Hii, King Kuok; Hill, Alison M. Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 639 - 647

~99%

BnO-PEG6-OH Structure

BnO-PEG6-OH

CAS#:24342-68-5

Literature: Pilkington-Miksa, Michael A.; Sarkar, Supti; Writer, Michele J.; Barker, Susie E.; Shamlou, Parviz Ayazi; Hart, Stephen L.; Hailes, Helen C.; Tabor, Alethea B. European Journal of Organic Chemistry, 2008 , # 17 p. 2900 - 2914

~70%

BnO-PEG6-OH Structure

BnO-PEG6-OH

CAS#:24342-68-5

Literature: Chen, Bin; Baumeister, Ute; Pelzl, Gerhard; Das, Malay Kumar; Zeng, Xiangbing; Ungar, Goran; Tschierske, Garsten Journal of the American Chemical Society, 2005 , vol. 127, # 47 p. 16578 - 16591

~19%

BnO-PEG6-OH Structure

BnO-PEG6-OH

CAS#:24342-68-5

Literature: Glaxo Wellcome Inc. Patent: US6355646 B1, 2002 ; Location in patent: Page column 13 ;

 Synonyms

1-Phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol
2,5,8,11,14,17-Hexaoxanonadecan-19-ol, 1-phenyl-
Hexaethylene Glycol Monobenzyl Ether
1-hydroxy-3,6,9,12,15,18-hexaoxa-19-phenyl-nonadecane
2-[2-[2-[2-[2-[2-(Benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
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