B-Raf IN 9

Modify Date: 2024-01-14 00:06:39

B-Raf IN 9 Structure
B-Raf IN 9 structure
Common Name B-Raf IN 9
CAS Number 2477725-18-9 Molecular Weight 400.50
Density N/A Boiling Point N/A
Molecular Formula C23H20N4OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of B-Raf IN 9


B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].

 Names

Name B-Raf IN 9

 B-Raf IN 9 Biological Activity

Description B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM[1].
Related Catalog
Target

B-Raf:24.97 ± 0. nM (IC50)

References

[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

 Chemical & Physical Properties

Molecular Formula C23H20N4OS
Molecular Weight 400.50