N3-PEG3-CH2CH2-Boc structure
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Common Name | N3-PEG3-CH2CH2-Boc | ||
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CAS Number | 252881-73-5 | Molecular Weight | 303.35500 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C13H25N3O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of N3-PEG3-CH2CH2-BocN3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
Name | N3(CH2CH2O)3CH2CH2COOt-Bu |
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Synonym | More Synonyms |
Description | N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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Related Catalog | |
Target |
PEGs Alkyl/ether Cleavable |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
Molecular Formula | C13H25N3O5 |
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Molecular Weight | 303.35500 |
Exact Mass | 303.17900 |
PSA | 103.74000 |
LogP | 1.53106 |
Hazard Codes | Xi |
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Precursor 0 | |
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DownStream 1 | |
tert-butyl 12-azido-4,7,10-trioxadodecanoate |
tert-butyl 12-azido-4,7,10-trioxadocecanoate |
12-azido-4,7,10-trioxadodecanoic acid tert-butyl ester |
3-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester |
N3-PEG3-CH2CH2COOtBu |