Propargyl-PEG3-Boc

Modify Date: 2023-01-16 23:52:39

Propargyl-PEG3-Boc Structure
Propargyl-PEG3-Boc structure
Common Name Propargyl-PEG3-Boc
CAS Number 1374658-84-0 Molecular Weight 272.337
Density 1.0±0.1 g/cm3 Boiling Point 337.2±27.0 °C at 760 mmHg
Molecular Formula C14H24O5 Melting Point N/A
MSDS N/A Flash Point 143.3±23.8 °C

 Use of Propargyl-PEG3-Boc


Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 3-{2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy}propanoate
Synonym More Synonyms

 Propargyl-PEG3-Boc Biological Activity

Description Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 337.2±27.0 °C at 760 mmHg
Molecular Formula C14H24O5
Molecular Weight 272.337
Flash Point 143.3±23.8 °C
Exact Mass 272.162384
LogP 1.25
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.452

 Synonyms

MFCD22201522
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 3-{2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy}propanoate
Propargyl-PEG3-t-butyl ester