HIF-2α agonist 2

Modify Date: 2024-04-06 18:26:02

HIF-2α agonist 2 Structure
HIF-2α agonist 2 structure
Common Name HIF-2α agonist 2
CAS Number 2750141-15-0 Molecular Weight 416.09
Density N/A Boiling Point N/A
Molecular Formula C13H8Br2N2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIF-2α agonist 2


HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1].

 Names

Name HIF-2α agonist 2

 HIF-2α agonist 2 Biological Activity

Description HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1].
Related Catalog
In Vitro HIF-2α agonist 2 (0.001-100 μM;24 h) 剂量依赖性地激活 HIF-2,在 20 μM 剂量下 EC50 值为 1.68 μM[1]。 HIF-2α agonist 2 (0.003-20 μM;24 h) 对 786-O-Luc 细胞无细胞毒性[1]。 Cell Viability Assay[1] Cell Line: 786-O-HRE-Luc cell line Concentration: 0.003-20 μM Incubation Time: 24 hours Result: Showed no cytotoxicity to 786-O-Luc cells.
References

[1]. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999.  

 Chemical & Physical Properties

Molecular Formula C13H8Br2N2O2S
Molecular Weight 416.09
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