HIF-2α agonist 2

Modify Date: 2024-04-06 18:26:02

HIF-2α agonist 2 structure	Common Name	HIF-2α agonist 2
	CAS Number	2750141-15-0	Molecular Weight	416.09
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₈Br₂N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIF-2α agonist 2

HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1].

Name	HIF-2α agonist 2

Description	HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
In Vitro	HIF-2α agonist 2 (0.001-100 μM；24 h) 剂量依赖性地激活 HIF-2，在 20 μM 剂量下 EC50 值为 1.68 μM[1]。 HIF-2α agonist 2 (0.003-20 μM；24 h) 对 786-O-Luc 细胞无细胞毒性[1]。 Cell Viability Assay[1] Cell Line: 786-O-HRE-Luc cell line Concentration: 0.003-20 μM Incubation Time: 24 hours Result: Showed no cytotoxicity to 786-O-Luc cells.
References	[1]. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999.

Molecular Formula	C₁₃H₈Br₂N₂O₂S
Molecular Weight	416.09

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