Ac-Ile-Glu-Thr-Asp-AMC

Modify Date: 2024-01-02 18:47:00

Ac-Ile-Glu-Thr-Asp-AMC Structure
Ac-Ile-Glu-Thr-Asp-AMC structure
Common Name Ac-Ile-Glu-Thr-Asp-AMC
CAS Number 348079-17-4 Molecular Weight 675.683
Density 1.4±0.1 g/cm3 Boiling Point 1157.6±65.0 °C at 760 mmHg
Molecular Formula C31H41N5O12 Melting Point N/A
MSDS N/A Flash Point 653.9±34.3 °C

 Use of Ac-Ile-Glu-Thr-Asp-AMC


Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity[1].

 Names

Name N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-methyl-2-oxo-2H -chromen-7-yl)-L-α-asparagine
Synonym More Synonyms

 Ac-Ile-Glu-Thr-Asp-AMC Biological Activity

Description Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity[1].
Related Catalog
References

[1]. V Frost, et al. Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells. Oncogene. 2001 May 17;20(22):2737-48.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1157.6±65.0 °C at 760 mmHg
Molecular Formula C31H41N5O12
Molecular Weight 675.683
Flash Point 653.9±34.3 °C
Exact Mass 675.275146
PSA 287.99000
LogP 1.24
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.585

 Synonyms

L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine