Eriodictyol
Eriodictyol structure
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Common Name | Eriodictyol | ||
|---|---|---|---|---|
| CAS Number | 552-58-9 | Molecular Weight | 288.252 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 625.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H12O6 | Melting Point | 270ºC | |
| MSDS | Chinese USA | Flash Point | 241.9±25.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of EriodictyolEriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | eriodictyol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity[1]. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons[2]. |
| In Vivo | Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues[1]. |
| Cell Assay | Primary cultures of cortical neurons are prepared from day 17 Sprague-Dawley rat embryos and maintained in Neurobasal A medium supplemented with B27. Experiments are performed 7 days after seeding. Aβ25-35 is dissolved in deionized distilled water at a concentration of 1 mM and incubated at 37°C for 7 days to induce its aggregation. Eriodictyol is added at indicated concentrations (20, 40, 80 μM) 2 h prior to Aβ25-35 treatment. Eriodictyol is dissolved in dimethyl sulfoxide (DMSO) at 64 mM as stock solution and diluted in culture medium before use[2]. |
| Animal Admin | Mice[1] Eighty female C57BL/6 mice are anesthetized by an intraperitoneal injection of 150 mg/kg ketamine HCl and 65 µg/kg xylazine hydrochloride. E. coli LPS is instilled intratracheally (25 µg in 50 µL sterile saline) during inspiration. The control mice receive PBS instillation, while the Eriodictyol- and vehicle-treated mice receive Eriodictyol (30 mg/kg, dissolved in PBS) and vehicle (PBS), respectively, orally 2 days prior to the induction of ALI. The mice are then sacrificed by an intravenous injection of thiopental 24 h after the induction of ALI. The thorax is opened and the blood is sampled by cardiac puncture. Simultaneously, three bronchoalveolar lavage (BAL) procedures are performed, each using 0.5 mL normal saline. The blood is centrifuged (2,000 × g, for 10 min at 4°C) and the serum is stored for further processing; the survival curve is then depicted using the Kaplan-Meier method[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 625.2±55.0 °C at 760 mmHg |
| Melting Point | 270ºC |
| Molecular Formula | C15H12O6 |
| Molecular Weight | 288.252 |
| Flash Point | 241.9±25.0 °C |
| Exact Mass | 288.063385 |
| PSA | 107.22000 |
| LogP | 2.59 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.725 |
| InChIKey | SBHXYTNGIZCORC-ZDUSSCGKSA-N |
| SMILES | O=C1CC(c2ccc(O)c(O)c2)Oc2cc(O)cc(O)c21 |
| Storage condition | ?20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 3 | |
CAS#:446-71-9
CAS#:480-18-2
CAS#:480-41-1
CAS#:491-70-3
CAS#:480-23-9
CAS#:57765-66-9This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Antiviral effect of methylated flavonol isorhamnetin against influenza.
PLoS ONE 10(3) , e0121610, (2015) Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc... |
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Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity.
Br. J. Nutr. 113(5) , 770-82, (2015) Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic β-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin ... |
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Amino acid, mineral, and polyphenolic profiles of black vinegar, and its lipid lowering and antioxidant effects in vivo.
Food Chem. 168 , 63-9, (2014) Black vinegar (BV) contains abundant essential and hydrophobic amino acids, and polyphenolic contents, especially catechin and chlorogenic acid via chemical analyses. K and Mg are the major minerals i... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00135890 |
| (S)-3',4',5,7-Tetrahydroxyflavanone |
| EINECS 209-016-4 |
| T66 BO EVT&J CR CQ DQ& GQ IQ &&S Form |
| (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one |
| (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one |
| Eriodictiol |
| (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone |
| Eriodictyol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of eriodictyol? |
| A: Molecular weight of eriodictyol is 288.252. |
| Q: What are the uses of eriodictyol? |
| A: Main uses of eriodictyol: Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. |
| Q: What are the storage conditions for eriodictyol? |
| A: Storage conditions for eriodictyol: ?20°C. |
| Q: What is the molecular formula of eriodictyol? |
| A: Molecular formula of eriodictyol is C15H12O6. |
| Q: What is the English name of eriodictyol? |
| A: The English name of eriodictyol is eriodictyol. |
| Q: What English synonyms does eriodictyol have? |
| A: English synonyms of eriodictyol: MFCD00135890, (S)-3',4',5,7-Tetrahydroxyflavanone, EINECS 209-016-4, T66 BO EVT&J CR CQ DQ& GQ IQ &&S Form, (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one, (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one, Eriodictiol, (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone, Eriodictyol. |
| Q: What is the polar surface area (PSA) of eriodictyol? |
| A: Polar surface area (PSA) of eriodictyol is 107.22000. |
| Q: What are the upstream materials of eriodictyol? |
| A: Related upstream materials(CAS) of eriodictyol: 446-71-9;480-18-2;480-41-1. |
| Q: What are the downstream products of eriodictyol? |
| A: Related downstream products(CAS) of eriodictyol: 491-70-3;480-23-9;57765-66-9. |
| Q: What is the CAS number of eriodictyol? |
| A: CAS number of eriodictyol is 552-58-9. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |
| Henan Tianfu Chemical Co., Ltd. |