SPDP-PEG4-acid

Modify Date: 2024-01-09 21:56:52

SPDP-PEG4-acid Structure
SPDP-PEG4-acid structure
Common Name SPDP-PEG4-acid
CAS Number 581065-97-6 Molecular Weight 462.581
Density 1.3±0.1 g/cm3 Boiling Point 677.3±55.0 °C at 760 mmHg
Molecular Formula C19H30N2O7S2 Melting Point N/A
MSDS N/A Flash Point 363.4±31.5 °C

 Use of SPDP-PEG4-acid


SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 17-Oxo-19-(2-pyridinyldisulfanyl)-4,7,10,13-tetraoxa-16-azanonadecan-1-oic acid
Synonym More Synonyms

 SPDP-PEG4-acid Biological Activity

Description SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 677.3±55.0 °C at 760 mmHg
Molecular Formula C19H30N2O7S2
Molecular Weight 462.581
Flash Point 363.4±31.5 °C
Exact Mass 462.149445
LogP 0.63
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.563

 Synonyms

17-Oxo-19-(2-pyridinyldisulfanyl)-4,7,10,13-tetraoxa-16-azanonadecan-1-oic acid
4,7,10,13-Tetraoxa-16-azanonadecan-1-oic acid, 17-oxo-19-(2-pyridinyldithio)-
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