Methylamino-PEG4-acid HCl

Modify Date: 2024-01-07 07:16:34

Methylamino-PEG4-acid HCl Structure
Methylamino-PEG4-acid HCl structure
Common Name Methylamino-PEG4-acid HCl
CAS Number 1283658-71-8 Molecular Weight 279.330
Density 1.1±0.1 g/cm3 Boiling Point 405.5±40.0 °C at 760 mmHg
Molecular Formula C12H25NO6 Melting Point N/A
MSDS N/A Flash Point 199.1±27.3 °C

 Use of Methylamino-PEG4-acid HCl


Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Methylamino-PEG4-acid
Synonym More Synonyms

 Methylamino-PEG4-acid HCl Biological Activity

Description Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 405.5±40.0 °C at 760 mmHg
Molecular Formula C12H25NO6
Molecular Weight 279.330
Flash Point 199.1±27.3 °C
Exact Mass 279.168182
LogP -1.62
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.458

 Synonyms

5,8,11,14-Tetraoxa-2-azaheptadecan-17-oic acid
MFCD28064328