THP-PEG3-OH

Modify Date: 2024-01-02 13:03:57

THP-PEG3-OH Structure
THP-PEG3-OH structure
Common Name THP-PEG3-OH
CAS Number 60221-37-6 Molecular Weight 234.28900
Density N/A Boiling Point N/A
Molecular Formula C11H22O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of THP-PEG3-OH


THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 THP-PEG3-OH Biological Activity

Description THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C11H22O5
Molecular Weight 234.28900
Exact Mass 234.14700
PSA 57.15000
LogP 0.55510

 Synonyms

2-{2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethanol
8-(2H-tetrahydropyran-2-yloxy)-3n36-dioxaoctan-1-ol
8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol
Ethanol,2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]
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