Thalidomide-NH-C2-PEG3-OH

Modify Date: 2024-01-14 20:20:35

Thalidomide-NH-C2-PEG3-OH structure	Common Name	Thalidomide-NH-C2-PEG3-OH
	CAS Number	2140807-23-2	Molecular Weight	449.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₇N₃O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-NH-C2-PEG3-OH

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].

Name	Thalidomide-NH-C2-PEG3-OH

Description	Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].
References	[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

Molecular Formula	C₂₁H₂₇N₃O₈
Molecular Weight	449.45

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Thalidomide-NH-C2-PEG3-OH
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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