Aurin

Modify Date: 2025-08-24 21:09:53

Aurin Structure
Aurin structure
 Common Name Aurin
CAS Number 603-45-2 Molecular Weight 290.31
Density 1.3±0.1 g/cm3 Boiling Point 543.0±50.0 °C at 760 mmHg
Molecular Formula C19H14O3 Melting Point ca. 308ºC (decomposes)
MSDS USA Flash Point 296.2±26.6 °C

 Use of Aurin


Rosolic Acid is an activator of Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α and IL-1β) and apoptotic markers (CXCL10 and CCL2). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed[1].

 Names

Name 4-[bis(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one
Synonym More Synonyms

 Aurin Biological Activity

Description Rosolic Acid is an activator of Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α and IL-1β) and apoptotic markers (CXCL10 and CCL2). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed[1].
Related Catalog
References

[1]. Amin KN, et al. Effect of Rosolic acid on endothelial dysfunction under ER stress in pancreatic microenvironment. Free Radic Res. 2021 Jun;55(6):698-713.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 543.0±50.0 °C at 760 mmHg
Melting Point ca. 308ºC (decomposes)
Molecular Formula C19H14O3
Molecular Weight 290.31
Flash Point 296.2±26.6 °C
Exact Mass 290.094299
PSA 57.53000
LogP 3.15
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.691
InChIKey FYEHYMARPSSOBO-UHFFFAOYSA-N
SMILES O=C1C=CC(=C(c2ccc(O)cc2)c2ccc(O)cc2)C=C1
Storage condition Store at room temperature.
Water Solubility Solubility Practically insoluble in water, benzene; freely soluble in ethanol

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2914501900

 Synthetic Route

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles15

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Ligand polarizability contributes to tau fibril binding affinity.

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Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship.

Microbios 78(315) , 83-90, (1994)

The activity of 45 compounds against bloodstream forms of Trypanosoma cruzi was investigated. The aim was to consider new agents which might subsequently be assayed for chemoprophylaxis in donated blo...

Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5.5 and pH 9.0. A pH-induced conformational transition involves a peptide bond flip.

J. Mol. Biol. 221(3) , 765-72, (1991)

The X-ray crystal structure of recombinant wild-type azurin from Pseudomonas aeruginosa was determined by difference Fourier techniques using phases derived from the structure of the mutant His35Leu. ...

 AurinBioassay

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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
Name: Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Lum...
Source: The Scripps Research Institute Molecular Screening Center
Target: transactivating tegument protein VP16 [Human herpesvirus 1]
External Id: VP16_INH_LUMI_1536_3X%INH CSRUN for SRC1
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Luminescence-based cell-based high throughput confirmation assay for inhibitors of th...
Source: The Scripps Research Institute Molecular Screening Center
Target: nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
External Id: SRC1_INH_LUMI_1536_3X%INH CRUN
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 Synonyms

4-(p,p'-Dihydroxybenzhydrylidene)-2,5-cyclohexadien-1-one
Aurin No. 555
MFCD00001624
EINECS 210-041-8
4-[bis(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one
Aurin
4-<bis(4-hydroxyphenyl)methylene>-2,5-cyclohexadienone
rosolic acid
4-[Bis(4-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one
Corallin Spirit Soluble
4,4'-Dihydroxyfuchsone
4-(Bis(p-hydroxyphenyl)methylene)cyclohexa-2,5-dien-1-one
4-[bis(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one
Aurine
Corallin
p-Rosolic acid
Spirit Aurine
4-[bis-(4-hydroxyphenyl)methylene]-cyclohexa-2,5-dienone
Rosalic Acid
CI 43800
Pararosolic Acid
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Chemsrc provides Aurin(CAS#:603-45-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Aurin are included as well.>> amp version: Aurin

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